Endocrine Abstracts

Introduction: Thyroid hormones are the most important factors involved in the regulation of the basal metabolic state, as well as in the oxidative metabolism. Oxidative stress accompanying hyperthyroidism is caused by increased synthesis of reactive oxygen species (ROS) and changes in the antioxidant defence system.Aim of the study: To evaluate the pro-oxidant/antioxidant status and the effect of vitamin E supplementation in damage caused by the excessiv...

It has been shown that aging is associated with ‘physiological’ alterations in both the hypothalamo–pituitary–thyroid axis and at the peripheral level such as elevation of basal TSH levels, often with normal T3 and T4 levels and decreased nuclear binding of thyroid hormones, particularly of T3. The frequency of nodular goiter and of an altered thyroid status increases with advancing age. The aim of our study was to analyze t...

Periodontal changes are induced by hormonal alterations through soft tissue oedema, inflammation, demineralization or abnormal periosteal development of the alveolar bones.Objectives: The purpose of the present work was to evaluate the frequency, severity and type of periodontal disease in subjects with previously diagnosed and non-treated pituitary disorders.Patients and methods: Twenty-five subjects (21 women and 4 men) aged 44.7...

Background and objective: One of the key features of thyroid gland cancer evaluated at palpation is the degree of firmness: malignant lesions tend to be much harder than benign ones. US elastography is combining the diagnostic advantages of high-frequency US examination and the accuracy of thyroid cancer diagnosis based on the lesion’s stiffness. The aim of our prospective study was to evaluate the elastographic appearance of thyroid gland tumours and to explore the sensi...

Background: The aim of this case report is to underline the possible etiological link between paroxysmal supraventricular tachycardia (PSVT) and hypothyroidism, although supraventricular arrhythmias are ordinary features of hyperthyroidism. We present the case of a patient with repetitive episodes of PSVT whose autoimmune hypothyroidism was diagnosed and thyroxin replacement therapy leaded to remission of arrhythmia.Methods: A 47 year old women with a lo...

Background: Glucocorticoid resistance syndrome is a rare, familial or sporadic disease, caused by genetic mutations of the glucocorticoid receptor or at any other level of the signaling pathway. It is characterized by general, partial, target-tissue insensitivity to glucocorticoids, leading to activation of the hypothalamo–hypophysis–adrenal axis resulting in compensatory increased levels of cortisol, but also increased concentrations of adrenal products with mineral...

The empty sella syndrome (ESS) is caused by the herniation of the suprarahnoidian space into the sella turcica, generating the compression of the pituitary gland and, in most cases, a remodelling of the sella. The purpose of this study was to evaluate the etiology, the degree of hormonal deficit and the occurrence rate of the signs and symptoms accompanying ESS.Material and methods: We performed a descriptive, retrospective study by analysing the medical...

Introduction and purpose: Acromegaly is characterised by a chronic increase of GH and IGF-1 levels that may induce various clinical symptoms and multisystem comorbidities. The purpose of this study is to evaluate the type and frequency of thyroid disease most often associated with acromegaly patients.Material and methods: We conducted a retrospective observational study analysing the data from the observation charts of 77 patients with acromegaly (58 fem...

About 1% of the patients with Graves’ disease develop myasthenia gravis, however, euthyroid Graves’ ophtalmopathy has only rarely been associated with myasthenia gravis and especially with isolated ocular myasthenia gravis. A 63-year old, male patient with vitiligo presented double vision and right ptosis, shortly followed by left ptosis. On the ophthalmological examination there was bilateral ptosis and orbito-ocular ultrasonography yielded a thickening of the left ...

Introduction: Sexual dysfunction is a particular pathology with relative high prevalence, often underestimated in general population. It’s manifest as an impairment of sexual desire, orgasm, sexual excitement or pain related to intercourse. Although often recognize a psychogenic cause, sexual dysfunction are found also in various systemic diseases more or less related to changes of sexual hormones. Thyroid pathology, particularly hyper and hypothyroidism, with high freque...